Tsui TL, Huang YT, Kan WC, et al. - Wide investigation has been made for procalcitonin (PCT) as an infection biomarker. Researchers sought to demonstrate that serum PCT, combining with other relevant variables, has an even better ability for detecting sepsis in critically ill patients. In this retrospective cohort study, they enrolled a total of 258 critically ill patients (70.9±16.3 years; 55.4% man) in the derivation cohort and further subgrouped them into the sepsis group (n = 115) and the non-sepsis group (n = 143). The multivariate logistic regression analysis led to disclosure of five independent factors for identifying sepsis, namely, “serum PCT level,” “albumin level” and “neutrophil-lymphocyte ratio” at ICU admission, along with “diabetes mellitus,” and “with vasopressor.” A PCT-based score containing the five weighted factors was subsequently built. This novel PCT-based score was identified to perform better in detecting sepsis than serum PCT levels alone, C-reactive protein, and infection probability score.