Smullin C, Wagman J, Mehta S, et al. - In the United States from 1980 to 2019, the epidemiological trends in congenital syphilis (CS) and traits of mothers of infants with CS were described in this review. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for reporting of observational studies in epidemiology, researchers conducted this narrative review of epidemiological studies of CS. The Newcastle-Ottawa Scale was applied to evaluate the quality and bias of the studies that were used, of which there were 2,771, with 27 of them included in the final analysis. Certain subgroups of women were affected by infection with and antepartum transmission of syphilis disproportionately. During pregnancy, women who report substance use are more likely to give birth to an infant with CS. The data exhibited that no prenatal care and evidence of inadequate syphilis testing and treatment during pregnancy are also significantly associated with giving birth to an infant with CS. Also, African American women were influenced by cases of CS disproportionately. Addressing the CS epidemic will need identification and targeted allocation of resources to communities at increased risk for syphilis, removal of barriers to prenatal care, and ensuring timely treatment and adequate partner notification of identified cases.