Shah R, et al. - In the context of contemporary aggressive preventive strategies, researchers assessed the role of aspirin for the primary prevention of cardiovascular diseases via performing a meta-analysis of 14 randomized, controlled trials involving 164,751 patients. According to findings, the effect of aspirin on myocardial infarction risk was significantly reduced in the context of contemporary primary prevention guidelines; however, its major bleeding and hemorrhagic stroke complications were retained. Thus, the routine use of aspirin for the primary prevention of cardiovascular events in contemporary practice can have a net harmful effect. Differences in risk of all-cause stroke, cardiac death, and all-cause mortality between aspirin and placebo were not found.