Ross JL, et al. - Researchers examined adolescents living with HIV (ALHIV) aged 12-18 years at 9 sites in Malaysia regarding behavioral risks and antiretroviral therapy outcomes. They identified 250 ALHIV and 59 HIV-uninfected controls (58% Thai and 51% females; median age 14 years at enrollment). Perinatal infection was reported in 93% of ALHIV. At week 144, 66% of ALHIV vs 28% of controls were orphans. ALHIV and controls in similar proportion reported drinking alcohol, using inhalants, consistency of using condoms, and being sexually active. Virologic failure (VF) at any time was noted to be associated with smoking cigarettes, >1 sexual partner, and living with nonparent relatives, a partner or alone. Findings emphasize addressing sexual risk, substance use, and HIV-status disclosure in comprehensive interventions for the subset of ALHIV with poorer adherence and VF.