Fortier M, et al. - In view of the fact that, unlike glucose, the uptake of the main alternate fuel of the brain (ketones) stays normal in mild cognitive impairment (MCI), researchers wanted to know if giving the brain more fuel with a ketogenic drink could improve brain energy and cognitive measures in MCI. For this investigation, 52 MCI patients were randomized blindly to 30 g/day of ketogenic medium chain triglyceride (kMCT) or matching placebo. For subjects on kMCT, brain ketone metabolism increased by 230%, while the uptake of brain glucose was unchanged. Compared to baseline, measures of episodic memory, language, executive function, and processing speed improved in patients on kMCT, as did net brain energy. There was a positive association between increased brain ketone uptake and several cognitive measures. The data presented in this work showed a 30 g/day dose of kMCT taken for six months is a way around a significant part of the brain glucose deficit and enhances several cognitive outcomes in MCI. Both kMCT and placebo were tolerated moderately well.