Bruttomesso D, et al. – In a cohort of 8 men with type 1 diabetes mellitus (T1DM), researchers assessed the kinetics of whole-body protein in association with consumption of a high-fiber diet (HFD) under both basal-low insulinemic and hyperinsulinemic conditions. Participants were analyzed twice—before and following the addition of guar gum (∼15 g/d) to their usual diet for approximately 4 months. In men with T1DM, a downregulation of post-absorptive protein turnover by an HFD was evident. This effect was induced by decreasing both protein degradation and synthesis, most likely because of a subtle decrease and/or delay in amino acid absorption. No significant impact was evident on insulin (and amino acid sensitivity) to protein turnover, glucose disposal, and metabolic control.