Moon JY, et al. - In US Hispanics/Latinos with diverse genetic ancestries, researchers identified hemoglobin A1c (HbA_1c)-associated genetic variants and analyzed their impact for glycemic status assessed by HbA_1c. They performed a genome-wide association study (GWAS) of HbA_1c in 9,636 U.S. Hispanics/Latinos without diabetes from the Hispanic Community Health Study/Study of Latinos, followed by a replication among 4,729 US Hispanics/Latinos from three independent studies. Findings revealed that hyperglycemia (prediabetes and diabetes) prevalence (defined utilizing fasting glucose or oral glucose tolerance test 2-hour glucose) was comparable between carriers of HBB-rs334 or G6PD-rs1050828 HbA_1c-lowering alleles and noncarriers; the hyperglycemia prevalence (defined using HbA_1c) was significantly lower in carriers vs noncarriers. This study in US Hispanics/Latinos discovered several ancestry-specific alleles linked to HbA_1c through erythrocyte-related instead of glycemic-related pathways. When the HbA_1c test is performed, the potential influences of these nonglycemic-related variants must be considered.