Xia J, et al. - In patients with acute coronary syndrome (ACS) researchers explored the link between apolipoprotein E (ApoE) gene polymorphisms and major adverse cardiovascular events (MACE) during a 6-month follow-up. They observed that E4 allele carriers were associated with higher low-density lipoprotein (LDL) cholesterol, total cholesterol (TC) levels, and a higher incidence of MACE.

Methods

• For this investigation, 211 subjects were admitted to a cardiology clinic with a diagnosis of ACS from October 2016 to July 2017.
• On the first day, blood samples were obtained from all patients.
• A 6-month incidence of MACE was the primary end point.
• Using TaqMan® SNP Genotyping Assay, ApoE gene polymorphism was genotyped by real-time PCR.

Results

• Compared with the patients without the E4 allele (p=0001 and p=0.001), the patients with the E4 allele were related to higher LDL cholesterol and TC levels.
• Compared with the patients without the E4 allele (ApoE4 allele(+) 23.1% vs ApoE4 allele(-) 9.3%; p=0.03), the patients with the E4 allele were correlated with a higher rate of MACE .
• Multivariable analysis recommended that E4 allele carriers demonstrated an 85% risk increment of 6-month MACE (odds ratio 2.48, 95% confidence interval 2.37–5.95; p=0.01).