Vareechon C, et al. - Considering the significance of high accuracy of direct from positive blood culture molecular panels, particularly for the detection of resistance determinants, for antimicrobial optimization prior to conventional susceptibility testing, researchers review the extensive data since implementation of the Verigene Gram-positive blood culture panel (BC-GP) in 2013. They recognized a total of 1636 blood culture bottles positive for a Gram-positive organism that were tested on the BC-GP panel within 5 years. As per outcomes, the BC-GP panel exhibited excellent performance, and in the absence of mecA and vanA/B gene, clinicians can confidently de-escalate antimicrobial therapy.