Toth D, et al. – Aim of this research was to propose a fundamentally different registration technique which uses adjacent anatomical structures with superabundant vessel reconstruction and dynamic outlier rejection. The proposed approach has been qualitatively and quantitatively assessed on phantom, clinical CT angiography with ground truth and clinical cardiac resynchronization therapy data. It was showed that a novel evaluation method is proposed for clinical cardiac resynchronization therapy data based on previously implanted artificial aortic and mitral valves. In addition, the registration accuracy in 3D was 2.94 mm for the aortic and 3.86 mm for the mitral valve.