Wang N, Jin F, Liu W, et al. - Considering the importance of safer, more effective and less painful anesthesia methods for the bronchoscopy success rate, researchers here evaluated the efficacy of 1% tetracaine hydrochloride injection pure solution aerosol inhalation combined with oral administration of dyclonine hydrochloride mucilage during bronchoscopy. They performed random assignment of 523 patients to either of the two groups; group A received pure tetracaine hydrochloride injection solution (3 mL of 1% tetracaine hydrochloride) aerosol inhalation combined with oral 5 mL of dyclonine hydrochloride mucilage and group B received diluted tetracaine hydrochloride injection (3 mL of 1% tetracaine hydrochloride injection + 3 mL of sterile water for injection) aerosol inhalation combined with oral 5 mL of dyclonine hydrochloride mucilage. As per the results, patients in group A vs group B had significantly better tolerance, cough response, glottis opening during the bronchoscope into the glottis and the time required to the tracheoscope pass through the glottis. Further, patients in group A vs group B had more stable vital signs including blood pressure, heart rate, and pulse oxygen saturation. These findings support the efficacy and safety of the 1% tetracaine hydrochloride injection pure liquid aerosol inhalation combined with oral administration of dyclonine hydrochloride mucilage as upper airway anesthesia for bronchoscopy. Clinical application of this method of local anesthesia is worth to be considered.