The architecture of each person’s brain is unique, and differences may influence how quickly people can complete various cognitive tasks.

But how neuroanatomy impacts performance is largely an open question.

To learn more, scientists are developing a new tool—computational models of the brain—to simulate how the structure of the brain may impact brain activity and, ultimately, human behavior. The research focuses on interconnectivity within the brain, looking at how different regions are linked to and interact with one another (traits that vary between individuals).

In an initial proof-of-concept study, a team led by University at Buffalo mathematician Sarah Muldoon finds that this approach shows promise for understanding the interplay between brain structure and performance on language-related tasks. The research was published in PLOS Computational Biology on October 17.

“We are creating these personalized brain network models to understand what the brain is doing, based on how connected different regions of a person’s brain are to one another,” says first author Kanika Bansal, a postdoctoral researcher jointly working at UB, the US Army Research Laboratory (ARL), and Columbia University.

“Models like this are powerful tools because they allow us to conduct ‘in silico’ experiments to understand brain function on a personal basis,” adds Muldoon, PhD, assistant professor of mathematics in the UB College of Arts and Sciences and a faculty member in UB’s Computational and Data-Enabled Science and Engineering and Neuroscience programs.

The power of a personalized brain model

In the new study, researchers created data-driven mathematical models of the individual brains of 10 people based on diffusion spectrum images, which capture the structural wiring of the subjects’ actual brains.

Scientists then used the models to learn about each person’s brain, including:

•How easily the brain jumps into an active state when it’s stimulated.
•Which brain regions become synchronized, exhibiting similar activity, when the left inferior frontal gyrus, an area of the brain important to language, is stimulated.

The research identified some relationships between these characteristics of the brain and how quickly people were able to carry out three language-demanding tasks: saying the first verb that came to mind when presented with a noun; filling in a missing word in a sentence; and reading a large number. (Each participant completed each activity multiple times before and after receiving transcranial magnetic stimulation to the left inferior frontal gyrus.)

While small, the study demonstrates the potential of data-driven modeling for learning about the link between brain structure and task performance.

—Newswise